Course: Gynecologic cytology

  • Introduction

    The total length of study is 8 hours (1 hour = 45 minutes).

    For each course you have to watch a presentation with spoken commentary (video) and take a test. There is no time limit for passing the test, but you have 5 attempts for each test.

    This is a set of 4 courses that cover the following topics:

    • Course 1: Cells with the potential for litigation
    • Course 2: Knowledge about the pathogenesis of squamous cell carcinoma of the cervix in 2020
    • Course 3: New IECC classification of endocervical adenocarcinomas and its effects on gynecological cytology
    • Course 4: Multinucleated cells in gynecological cytology

    Study of courses is free. Issuance of certificates for their successful completion is charged (800 CZK, 31 EUR). It is free for users from Charles University.

    Courses cannot be purchased separately, only as a whole set.

    We are applying for EACCME accreditation. 

    Contacts:

    • Communication with the author and tutor of the course: ondic@biopticka.cz
    • In case of technical problems: postudium@lfp.cuni.cz

    • Courses
    1
    2
    3
    4
    Certificates
    5
    Notes
    6
    7

  • Course 1: Litigation cells

    Ikona delky trvaniThe length of the course is 2 hours

    The presentation deals with the cells and situations that are the cause of false negativity of some results of gynecological screening cytology. At the same time, it characterizes the false negativity and points out the ways to deal with it in the setting of routine laboratory work-flow. The presentation is followed by a test imitating the reading of a slide in routine practice. 

    What will you learn?

    Upon finishing the course, you will be able to define litigation cells. You will understand false negativity in cervical cancer screening and be capable of tackling this issue by some changes of laboratory procedures. Also, you will be aware of „risky slides“, and you will train how to approach them in a daily screening routine.  


  • Course 2: Our understanding of the pathogenesis of cervical sqamous cell carcinoma in 2020

    The length of the course is 2 hours

    The presentation summarizes current knowledge about the carcinogenesis of squamous cell carcinoma of the cervix. It describes the individual stages and also points out gaps in our knowledge. The improvements in our knowledge are associated with possible practical implications. 

    What will you learn?

    Upon finishing the course, you will be able to describe six carcinogenesis stages leading to cervical cancer, including selected basic knowledge regarding some epigenetic changes participating in the process.


  • Course 3: New IECC classification of endocervical adenocarcinomas

    Ikona delky trvani The length of the course is 2 hours

    The presentation explains the essence of classification in the context of knowledge of histology and molecular genetics. Shows cytological correlation. It comments on the consequences of the new classification of endocervical adenocarcinomas for cytological screening and gynecological practice. 

    What will you learn?

    Upon finishing the course, you will be familiar with the background and understand the basis for a new WHO 2020 classification of cervical adenocarcinoma.


  • Course 4: Multinucleated cells in gynecological cytology

    Ikona delky trvaniThe length of the course is 2 hours

    The course categorizes the different types of multinucleated cells that may be present in PAP coatings. Provides the context of clinical information and / or histological diagnosis to each giant cell type. The course presents the recently described type of HSIL and a rare type of invasive squamous cell carcinoma.

    What will you learn?
    Upon finishing the course, you will be able to identify five types of multinucleated cellular structures and their histologic/clinical counterparts. You will be familiar with a newly described subtype of HSIL and an extremely rare type of cervical squamous cell carcinoma.


  • Certificates

    • url icon
      Certificate: Litigation cells URL
      Not available unless: The activity Certificate: Litigation cells is marked complete
    • url icon
      Certificate: Our undestanding of the pathogenesis of cervical sqamous cell carcinoma in 2020 URL
      Not available unless: The activity Certificate: Our understanding of the pathogenesis of cervical sqamous cell carcinoma in 2020 is marked complete
    • url icon
      Certificate: New IECC classification of endocervical adenocarcinomas URL
      Not available unless: The activity Certificate: New IECC classification of endocervical adenocarcinomas is marked complete
    • url icon
      Certificate: Multinucleated cells in gynecological cytology URL
      Not available unless: The activity Certificate: Multinucleated cells in gynecological cytology is marked complete

  • About the Author

    Dr. Ondrej Ondič, Ph.D., FIAC is a practicing surgical pathologist in both private and academic pathology departments. He is a faculty member at Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic. His practice and research focus is primarily on gynecologic pathology including PAP smears. The private pathology laboratory – Biopticka Laboratory s.r.o, is one of the largest fully integrated biopsy-cytology-molecular pathology centers in Europe. Its yearly PAP smear volume is the largest in the world (with no available data from China).   

    https://www.biopticka.cz/en/laboratory/staff/ondic.php#


    List of Publications:

    1. The newly proposed International Endocervical Adenocarcinoma Criteria and Classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases.

    Ondič O, Němcová J, Alaghehbandan R, Černá K, Gomolčáková B, Kinkorová-Luňáčková I, Chytra J, Šidlová H, Hósová M, Bouda J.

    Cytopathology. 2020 Jul;31(4):288-291. doi: 10.1111/cyt.12831. Epub 2020 Jun 14.

    PMID: 32289186


    2. ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nascens with cytoplasmic signet ring cell change.

    Ondič O, Bednářová B, Ptáková N, Hájková V, Šteiner P, Šidlová H, Presl J, Bouda J, Alaghehbandan R, Michal M.

    Virchows Arch. 2020 Apr;476(4):615-619. doi: 10.1007/s00428-020-02744-5. Epub 2020 Jan 14.

    PMID: 31938824


    3. The detection of DNA methylation of tumour suppressor genes in cervical high-grade squamous intraepithelial lesion: A prospective cytological-histological correlation study of 70 cases.

    Ondič O, Němcová J, Alaghehbandan R, Černá K, Gomolčáková B, Kinkorová-Luňáčková I, Chytra J, Šidlová H, Májek O, Bouda J.

    Cytopathology. 2019 Jul;30(4):426-431. doi: 10.1111/cyt.12718.

    PMID: 31074057


    4. On Histologic Variability of HPV-associated Endocervical Adenocarcinomas.

    Ondič O, Bouda J, Němejcová K, Kajo K, Hegedüs L, Alaghehbandan R.

    Am J Surg Pathol. 2019 Jun;43(6):863-865. doi: 10.1097/PAS.0000000000001259.

    PMID: 30994536 No abstract available.


    5. Immunohistochemical and selected genetic reflex testing of all uterine leiomyosarcomas and STUMPs for ALK gene rearrangement may provide an effective screening tool in identifying uterine ALK-rearranged mesenchymal tumors.

    Ptáková N, Miesbauerová M, Kosťun J, Grossmann P, Šidlová H, Pavelka J, Presl J, Alaghehbandan R, Bouda J, Ondič O.

    Virchows Arch. 2018 Nov;473(5):583-590. doi: 10.1007/s00428-018-2428-8. Epub 2018 Aug 16.

    PMID: 30116888


    6. Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response.

    Ondič O, Šidlová H, Alaghehbandan R.

    Int J Gynecol Pathol. 2020 Jan;39(1):e1. doi: 10.1097/PGP.0000000000000517.

    PMID: 29750704 No abstract available.


    7. Response to: High-grade squamous intraepithelial lesion (HSIL) of the cervix with bizarre cytological appearances ('pleomorphic HSIL').

    Ondič O, Alaghehbandan R.

    Pathology. 2018 Apr;50(3):369-370. doi: 10.1016/j.pathol.2017.09.023. Epub 2018 Mar 1.

    PMID: 29490871 No abstract available.


    8. Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases.

    Ondič O, Ferko R, Kičinová J, Bouda J, Kinkorová-Luňáčková I, Kupcová L, Zůchová M, Chytra J, Waloschek T, Tůmová Bartošková M, Alaghehbandan R, Němcová J.

    Cytopathology. 2018 Feb;29(1):58-62. doi: 10.1111/cyt.12494. Epub 2017 Nov 20.

    PMID: 29154448


    9. Bizarre cell dysplasia of the cervix.

    Ondič O, Ferko R, Kašpírková J, Švajdler M Jr, Rýchly B, Talarčík P, Bouda J, Michal M.

    J Obstet Gynaecol Res. 2017 Feb;43(2):345-351. doi: 10.1111/jog.13196.

    PMID: 28150409


    10. Fumarate Hydratase-deficient Uterine Leiomyomas Occur in Both the Syndromic and Sporadic Settings.

    Harrison WJ, Andrici J, Maclean F, Madadi-Ghahan R, Farzin M, Sioson L, Toon CW, Clarkson A, Watson N, Pickett J, Field M, Crook A, Tucker K, Goodwin A, Anderson L, Srinivasan B, Grossmann P, Martinek P, Ondič O, Hes O, Trpkov K, Clifton-Bligh RJ, Dwight T, Gill AJ.

    Am J Surg Pathol. 2016 May;40(5):599-607. doi: 10.1097/PAS.0000000000000573.

    PMID: 26574848 Free PMC article.


    11. Genetic testing of leiomyoma tissue in women younger than 30 years old might provide an effective screening approach for the hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC).

    Martínek P, Grossmann P, Hes O, Bouda J, Eret V, Frizzell N, Gill AJ, Ondič O.

    Virchows Arch. 2015 Aug;467(2):185-91. doi: 10.1007/s00428-015-1783-y. Epub 2015 May 19.

    PMID: 25985877


    12. Oligodendroglioma originating in mature cystic teratoma.

    Bartakova A, Ondic O, Presl J, Vlasak P, Bouda J.

    J Obstet Gynaecol. 2016;36(2):269-70. doi: 10.3109/01443615.2015.1049990. Epub 2015 Oct 14.

    PMID: 26467502 No abstract available.


    13. Extraintestinal oxyuriasis - report of three cases and review of literature.

    Ondič O, Neubauer L, Sosna B.

    Cesk Patol. 2014 Jul;50(3):152-4.

    PMID: 25186597 Review.


    14. Eosinophilic dysplasia of the cervix associated with HPV 6 infection - case report and review of the literature.

    Ondič O, Kašpírková J, Ferko R.

    Cesk Patol. 2013 Oct;49(4):146-8.

    PMID: 24289485 Review.


    15. HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women.

    Ondič O, Kašpírková J, Májek O, Kinkorová I.

    Virchows Arch. 2014 Jan;464(1):79-83. doi: 10.1007/s00428-013-1511-4. Epub 2013 Nov 26.

    PMID: 24276406


    16. [The testing strategy for detection of biologically relevant infection of human papillomavirus in head and neck tumors for routine pathological analysis].

    Kašpírková J, Ondič O, Cerná K, Skálová A.

    Cesk Patol. 2013 Jan;49(1):29-34.

    PMID: 23432073 Czech.


    17. Borderline papillary serous tumor of the fimbriated end of the fallopian tube with peritoneal implants.

    Ondic O, Kalis V, Sima R.

    J Obstet Gynaecol Res. 2011 Nov;37(11):1702-5. doi: 10.1111/j.1447-0756.2011.01556.x. Epub 2011 Jun 9.

    PMID: 21651651


    18. Morphological variations of scar-related and spontaneous endometriosis of the skin and superficial soft tissue: a study of 71 cases with emphasis on atypical features and types of müllerian differentiations.

    Kazakov DV, Ondic O, Zamecnik M, Shelekhova KV, Mukensnabl P, Hes O, Dvorak V, Michal M.

    J Am Acad Dermatol. 2007 Jul;57(1):134-46. doi: 10.1016/j.jaad.2006.11.036.

    PMID: 17572279


    19. Inflammatory myofibroblastic tumor of the uterus - case report.

    Štiková Z, Ptáková N, Horáková M, Kosťun J, Ondič O.

    Cesk Patol. 2019 Fall;55(4):239-243.

    PMID: 31842556 English.


    20. Eosinophilic dysplasia of the cervix associated with HPV 6 infection - case report and review of the literature.

    Ondič O, Kašpírková J, Ferko R. Cesk Patol. 2013 Oct;49(4):146-8.

    21. HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women.

    Ondič O, Kašpírková J, Májek O, Kinkorová I. Virchows Arch. 2014 Jan;464(1):79-83. doi: 10.1007/s00428-013-1511-4.


    22. Bizarre cell dysplasia of the cervix.

    Ondič O, Ferko R, Kašpírková J, Švajdler M Jr, Rýchly B, Talarčík P, Bouda J, Michal M. J Obstet Gynaecol Res. 2017 Feb;43(2):345-351. doi: 10.1111/jog.13196.


    23. Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases.

    Ondič O, Ferko R, Kičinová J, Bouda J, Kinkorová-Luňáčková I, Kupcová L, Zůchová M, Chytra J, Waloschek T, Tůmová Bartošková M, Alaghehbandan R, Němcová J. Cytopathology. 2018 Feb;29(1):58-62. doi: 10.1111/cyt.12494.


    24. Response to: High-grade squamous intraepithelial lesion (HSIL) of the cervix with bizarre cytological appearances ('pleomorphic HSIL').

    Ondič O, Alaghehbandan R. Pathology. 2018 Apr;50(3):369-370. doi: 10.1016/j.pathol.2017.09.023. Epub 2018 Mar 1.


    25. On Histologic Variability of HPV-associated Endocervical Adenocarcinomas.

    Ondič O, Bouda J, Němejcová K, Kajo K, Hegedüs L, Alaghehbandan R. Am J Surg Pathol. 2019 Jun;43(6):863-865. doi: 10.1097/PAS.0000000000001259.


    26. The detection of DNA methylation of tumour suppressor genes in cervical high-grade squamous intraepithelial lesion: A prospective cytological-histological correlation study of 70 cases.

    Ondič O, Němcová J, Alaghehbandan R, Černá K, Gomolčáková B, Kinkorová-Luňáčková I, Chytra J, Šidlová H, Májek O, Bouda J. Cytopathology. 2019 Jul;30(4):426-431. doi: 10.1111/cyt.12718.


    27. The newly proposed International Endocervical Adenocarcinoma Criteria and Classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases.

    Ondič O, Němcová J, Alaghehbandan R, Černá K, Gomolčáková B, Kinkorová-Luňáčková I, Chytra J, Šidlová H, Hósová M, Bouda J. Cytopathology. 2020 Jul;31(4):288-291. doi: 10.1111/cyt.12831. Epub 2020 Jun 14.

     



    • How to quote this course

      MUDr. Ondrej Ondič, Ph.D., FIAC: Gynecologic cytology. PO>STUDIUM [online] 20.7.2021 , poslední aktualizace 20.7.2021 [cit. doplňte aktuální datum]. Dostupný z WWW: https://postudium.cz/course/view.php?id=575. ISSN 1803-8999.